Study Gives Glimpse Into Future with Smart Biomedical Nanorobots: acsnano nanorobots biomedicine nanotechnology nanoscience
By Bhavna KavetiJul 19 2022Reviewed by Susha Cheriyedath, M.Sc. Controllable loading and monitoring of cargo molecules in real-time is critical in developing intelligent nanorobots. In an article recently published in the journal ACS Nano, gold nanodots encapsulated silica nanoparticles were prepared and grafted externally with poly , thereby achieving temperature-responsive nanorobots.
The prepared nanorobots were endowed with self-propulsion behavior, driven by enzymatic reactions. This propelling behavior of the nanorobots regulated the molecular cargo’s loading efficiency. Additionally, incorporating nickel into nanorobots enabled the magnet-guided transportation of cargo molecules under real-time Raman monitoring.
For practical applications of nanorobots in biomedical diagnosis and treatment, it is essential to control the nanorobot’s motion via in situ monitoring of the sampling molecules. Previously reported uses of nanorobots in biomedical applications include nanorobots with rough surfaces for preferential attachment of cancer cells in metastatic and primary lesions and antimicrobial nanorobots whose working was based on the principle of antibody−antigen interactions to capture Escherichia coli.
Initially, the Ni-incorporated ASPU nanoparticles -based nanorobots were injected into a clean area of a test chamber at a temperature of 37 degrees Celsius to demonstrate the temperature-sensitive working of the gate of nanorobots, which were in the closed state. The temperature control and self-propulsion induced by urease decomposition regulated the cargo loading efficiency. Temperature-regulated closing and opening of the gates on the PNIPAM shell protected the loaded cargo from the surrounding environment. Moreover, the feasibility test of biosampling nanorobots revealed their loading, targeting, encapsulation, and release functions via the real-time monitoring of cargo loading by Raman sensing.
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