Estrogens can be very helpful in preventing urine infections
Dear Dr. Roach: I was first diagnosed with breast cancer in 1987 at the age of 39. I was treated with a lumpectomy, radiation and 5-FU chemotherapy . Nine years ago, in the same breast, I had a small tumour and elected to have a bilateral mastectomy followed by a prescription of tamoxifen for seven years.
Estetrol is one of four human estrogens. It is sometimes called E4, to signify the fourth human estrogen. Unlike medicines such as Premarin that derive from horses, the medicine estetrol is the exact human hormone made only by the fetal liver. When given alone, estrogens increase the risk of endometrial cancer, but I was unable to confirm the 10% risk you quote. In studies using other estrogens, the risk of endometrial cancer for women taking estrogens alone is much lower, about 1%. It will be many years before the risk of endometrial cancer from estetrol takes effect.
Based on the limited data I found about estetrol, I don’t recommend it in a woman with a uterus, except when used in combination with a progesterone. However, I do recommend you discuss the use of topical estrogens to help reduce your risk of urine infections with your team of doctors . This should help solve your urine infection problem.
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