What is the impact of lower COVID-19 vaccine doses in younger cohorts? UofCalifornia SARSCoV2 COVID19 Vaccine Children Adolescents
By Shanet Susan AlexJul 18 2022Reviewed by Aimee Molineux A recent study published in the Open Forum Infectious Diseases journal evaluated the impact of the lower severe acute respiratory syndrome coronavirus 2 vaccine dosages in younger populations.
However, according to preliminary information from the New York State Department of Health, VE in children aged 5 to 11 decreased from 68 to 12%, and hospitalization rates from 100 to 48% during December 13, 2021, compared to January 24, 2022. On the other hand, VE in those aged 12 to 17 dropped from 66 to 51% for infections and from 85 to 73% for hospitalization.
Mechanisms of reduced vaccine efficacy in younger age groups One theory holds that the lower dosage of 10 µg of BNT162b2 delivered three weeks apart was the cause of the poor efficacy in children aged 5 to 11; however, evidence on neutralizing antibodies suggests that this was not the case.
After vaccination, T- and B-cell responses continue to develop for several months, as does immunity against severe illness. Therefore, the 51-day post-vaccination period for children aged 5 to 11 compared to 211 days for children aged 12 to 17 in New York might have attributed to the lower efficacy against hospitalization seen in the younger sample.
Altering the dose intervals was one action tried to enhance immunogenicity in individuals between the ages of 12 and 39. New research has shown that spreading out the initial and second doses of mRNA vaccines increases immunogenicity while reducing adverse reactions.
Canada Latest News, Canada Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Low rate of COVID-19 vaccination among high-risk pregnant womenLow rate of COVID-19 vaccination among high-risk pregnant women Coronavirus Disease COVID WomensHealth Pregnancy UpstateNews UMBaltimore LiebertPub
Read more »
The potential of circular RNA COVID-19 vaccinesThe potential of circular RNA COVID-19 vaccines Coronavirus Disease COVID RNA circularRNA mRNAvaccines WileyHealth
Read more »
Reduced desire for pregnancy during COVID-19 pandemicReduced desire for pregnancy during COVID-19 pandemic Coronavirus Disease COVID Pandemic Pregnancy WomensHealth JAMANetworkOpen UCSF UCBerkeley
Read more »
Study results encourage SARS-CoV-2–infected mothers breastfeed to protect infants from COVIDStudy results encourage SARS-CoV-2–infected mothers breastfeed to protect infants from COVID Antibodies ChildHealth Coronavirus Disease COVID SARSCoV2 breastmilk cordblood newborn pregnant glycoprotein
Read more »
The impact of glucocorticoid therapy on immune responses to COVID-19 vaccination or infection in rituximab-treated patients with autoimmune disordersThe impact of glucocorticoid therapy on immune responses to COVID-19 vaccination or infection in rituximab-treated patients with autoimmune disorders UniFAU COVID19 coronavirus covid vaccine vaccination autoimmune
Read more »
Study suggests COVID-19 vaccination may be associated with short-term changes in usual menstrual cycle lengthStudy suggests COVID-19 vaccination may be associated with short-term changes in usual menstrual cycle length HarvardChanSPH michiganstateu harvardmed BrighamWomens vaccine vaccination COVID19 coronavirus covid menstrualcycle menstruation
Read more »