Nature research paper: Somatic mosaicism reveals clonal distributions of neocortical development
) and their negative log10 P-value comparing individual values from both hemispheres . Size of markers, fill-color, and edge-color indicate a variant’s AF, significant lateralization, and P1,000×) was available; d: n = 522 pairs/118 variants; e: n = 416/117; f: n = 395/115. While all three cell types showed a significant positive correlation, neurons showed a higher correlation with oligodendrocytes than astrocytes, consistent with current knowledge about cellular origins.
Extended Data Fig. 8 Excitatory Neuron Marker TBR1 and Inhibitory Neuron Marker DLX1 Enable Dissection of Ventral and Dorsal Clone Contribution., TBR1+ sorted nuclei from ID01 show acetylation of H3K27 at promoter-specific for excitatory neurons but not for inhibitory neurons. DLX1+ sorted nuclei from ID01 show acetylation of H3K27 at promoter-specific for inhibitory neurons but not for excitatory neurons.
Extended Data Fig. 9 BEAST Lineage tree confirms manual clade assignment and UMAP Embedding of Mosaic Variants Suggests that Clade Variants Are Randomly Intermixed., Lineage tree for all considered cells using the filtered mosaic variants detectable in L-T from ID01. A representative tree was constructed using the maximum clade credibility method while branch colors represent inferred clades. Scale bar represents the expected substitutions per site as a function of branch length.
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