Nature research paper: Somatic genomic changes in single Alzheimer’s disease neurons
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Extended Data Fig. 1 Filtering of LiRA-called sSNVs to minimize single-cell artefacts from MDA amplification., Total pre-filtering LiRA-called sSNV per genome for control and AD single neurons. Single neuronal nuclei from prefrontal cortex and hippocampal CA1 underwent scWGS . Genome-wide counts of sSNV were determined using linked-read analysis .
The scWGS LiRA platform calls sSNVs that are linked by sequencing reads to heterozygous germline single nucleotide polymorphisms . A single-stranded lesion of DNA damage, such as oxidation or alkylation, is paired with an unmodified base on the opposite genomic strand, such that LiRA would not call a sSNV under conditions of sufficiently even sequencing coverage .
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