Scientists evaluate immunostimulatory glycolipid against SARS-CoV-2 infection researchsquare ColumbiaMed SARSCoV2 COVID19 Glycolipid
By Shanet Susan AlexJul 18 2022Reviewed by Aimee Molineux A recent study posted to the Research Square* preprint server showed that 7DW8-5, an immunostimulatory glycolipid impeded three respiratory viral infections, including severe acute respiratory syndrome coronavirus 2 , in vivo.
Natural killer T cells, a crucial component of innate immunity, are involved in autoimmune illnesses, cancer, and preventing infections. Invariant NKT cells are NKT cells that have a semi-invariant T-cell receptor , identifying particular glycolipids attached to CD1d molecules on antigen-presenting cells and set off a chain reaction of cytokines and chemokines. α-galactosylceramide , a glycolipid, was the first CD1d ligand to be discovered.
The team evaluated the hypothesis that 7DW8-5's immunostimulatory impact could hinder SARS-CoV-2 infection in mice. Further, they examined whether 7DW8-5 could lose its antiviral effectiveness due to repeated dosing, possibly resulting in NKT-cell anergy. Results and conclusions The team discovered that intranasal delivery of the immunostimulatory glycolipid 7DW8-5 prevented SARS-CoV-2 infection in wild-type mice. This was demonstrated by stable body weight and reduced viral replication in the lung by >2 logs.
The study results also depicted that 7DW8-5 has a host-directed and mechanism-specific activity. Although this glycolipid produced several chemokines/cytokines, its antiviral activity was eliminated in CD1d-knockout mice.
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