New cancer test 92% accurate
A new non-invasive diagnostic test for oral cancer test developed by researchers at the University of Surrey is said to be over 92% accurate at detecting oral squamous cell carcinoma and more than 80% accurate at identifying pre-cancerous oral epithelial dysplasia , according to a proof-of-concept study.
They reported that sensitivity of the index test was 86.8% and specificity 83.6% . Analysing OSCC samples separately led to higher diagnostic accuracy, with 92.0% sensitivity and 94.5% specificity.The test could pave the way for better oral cancer detection, the researchers said. The samples were collected in dental surgeries and mailed to their laboratory for analysis, which demonstrated that the test could be "used in primary care to identify patients in need of specialist care".
"Advanced cancer stage at time of diagnosis is one of the main factors accounting for the high mortality and morbidity of oral cancer," the researchers said, and this was "despite the accessibility of the oral mucosa to clinical inspection" because "a significant majority of patients present with locally advanced disease".
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