Scientists have discovered a new signaling pathway in the brain that controls food intake, and it could eventually give us improved treatments for binge eating – perhaps even a drug that turns off the desire to binge eat at the neural level.
– which regulates numerous metabolic processes – and that they can trigger sensations of hunger when activated. through a chemical chain of events, and by inhibiting ATX in mice, the researchers were able to control food cravings in the animals.
The pathway identified by the researchers shows AgRPs controlling levels of the biomolecule lysophosphatidylcholine in the blood. LPC molecules are transported to the brain and are turned into lysophosphatidic acid through ATX. "Our fundamental findings on the LPA-controlled excitability of the brain, which we have worked on for years, therefore also play a central role for eating behavior,"It's still early for the research, even though the initial results from this experiment on mice are promising. The team behind the study emphasizes that various other pathways also contribute to the body's requirement to get fed.
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