High-level resistance of SARS-CoV-2 BA.4 against neutralizing antibodies Antibodies Coronavirus Disease COVID SARSCoV2 Vaccine FcEffector biorxivpreprint nicd_sa WitsUniversity UPTuks UCT_news CAPRISAOfficial
By Dr. Priyom Bose, Ph.D.Jul 20 2022Reviewed by Benedette Cuffari, M.Sc. Since the beginning of the coronavirus disease 2019 pandemic, which is caused by the sudden outbreak of the severe acute respiratory syndrome coronavirus-2 , genomic evolution of the virus has occurred.
Over time, the Omicron variant has evolved into several sub-lineages including BA.2, BA.2.12.1, BA.4, and BA.5. Study findings BA.4 has been shown to evade nAbs induced by previous infection and vaccination. In the current study, BA.4 resistance was observed against nAbs and ADCC-mediating antibodies elicited by four VOCs, including D614G, Beta, Delta, and BA.1.
A greater reduction in neutralization against BA.4 occurred in unvaccinated individuals who recovered from COVID-19 caused by Delta or BA.1. To this end, autologous titers to the Delta spike protein were much higher as compared to those against D614G and Beta. Individuals who recovered from BA.1 infection showed reduced neutralization efficiency against BA.2 and BA.4.
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