Research could help drug developers improve the safety profiles of medications and reduce side effects.
Chemists overcome a major hurdle in synthesizing a more stable form of heterocycle -- a common component of most modern pharmaceuticals
"Azetidines are a particularly useful, stable form of heterocycle, but synthesizing them has been incredibly challenging," says Dr. Corinna Schindler, Canada Research Chair in synthetic solutions for bioactive compounds at UBC and senior author on the paper. Azetidines -- organic compounds that contain three carbon atoms and one nitrogen atom, and are liquid at room temperature -- are known to be metabolically robust and don't undergo oxidation reactions under physiological conditions.
Emily R. Wearing, Yu-Cheng Yeh, Gianmarco G. Terrones, Seren G. Parikh, Ilia Kevlishvili, Heather J. Kulik, Corinna S. Schindler.Until now, proteins have been the target of most medications for the prevention and treatment of human disease. Drug developers have perceived RNA to be too unstable to target with drug therapy. ...
Pharmaceuticals Controlled Substances Diseases And Conditions Organic Chemistry Chemistry Graphene Construction
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