A new study finds that the rate of genetic mutations of an animal determines its lifespan – the more the shorter
A recent study compares the accumulation of mutations across many animal species and aims to explore the role of these genetic changes in ageing and cancer.
“Whether evolutionary reduction of cancer risk across species is partly achieved by a reduction of somatic mutation rates remains unknown.”is named after epidemiologist Richard Peto, who noted the relationship between time and cancer when he was studying how tumours form in mice. Peto observed that the probability of cancer progression was related to the duration of exposure to the carcinogen benzpyrene.
Dr Adrian Baez-Ortega, a first author of the study from the Wellcome Sanger Institute, says: “The fact that differences in somatic mutation rate seem to be explained by differences in lifespan, rather than body size, suggests that although adjusting the mutation rate sounds like an elegant way of controlling the incidence of cancer across species, evolution has not actually chosen this path.
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