People with gout, especially women, appear to be at higher risk for poor COVID-19 outcomes, including hospitalization and death, regardless of COVID-19 vaccination status, researchers suggest. RheumTwitter
Arthritis & Rheumatology
The vaccinated cohort consisted of 54,576 people with gout and 1,336,377 without gout from the general population. The unvaccinated cohort included 61,111 individuals with gout and 1,697,168 individuals without gout from the general population.The risk for breakthrough infection in the vaccinated cohort was significantly higher among people with gout than among those without gout in the general population, particularly for men, who had hazard ratios ranging from 1.
Pamela B. Davis, MD, PhD, research professor at Case Western Reserve University, Cleveland, Ohio, told,"This study brings to attention yet another potentially vulnerable group for physicians to monitor closely if they are infected with SARS-CoV-2."It is not clear why women with gout are more vulnerable, but fewer women than men were in the cohort with gout, and the confidence intervals for the results in women were, in general, larger," she said.
Sarah E. Waldman, MD, associate clinical professor of infectious diseases at UC Davis Health in Sacramento, California, called the study interesting but not surprising."The reason for increased risk for COVID-19 infection among those with gout may have to do with their underlying inflammatory state. Additional research needs to be done on this topic.
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