The reason some people are seemingly unaffected by illness that impairs others is a great mystery of infectious disease, but answers to this question can unlock new therapies to curb outbreaks.
and other body fluids as well as on their red blood cells.
"What makes it particularly hard to study is the fact that there is no gold standard to measure infection," she says."So, what we do is infer infection from two different types of tests" -- a skin test and a blood test that measure different kinds of immune response to molecules from the bacterium. "That always seems to pop up everywhere. But the rest is not so obvious," she says."A lot of the studies don't find the same thing. It's different in different populations," which may be a result of the long evolutionary history between tuberculosis and humans, as well as the fact that different strains of the bacterium are prevalent in different parts of the world.
The group is recruiting people who did not become infected with COVID-19 despite heavy exposure, such as those living in households where all the other members got sick or people who were exposed to a superspreader event but did not become ill. As with tuberculosis, being certain that someone has not been infected with the virus can be tricky, but the team is using several blood tests to home in on the people most likely to have escaped infection.
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