Why brain aging can vary dramatically between people

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Why brain aging can vary dramatically between people
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Researchers are uncovering deeper insights into how the human brain ages and what factors may be tied to healthier cognitive aging, including exercising, avoiding tobacco, speaking a second language or even playing a musical instrument.

Researchers find that both genetic influences and lifestyle factors can affect an aging brain.

“We came up with the idea that ‘Marginal Gains, Not Magic Bullet’ is a good way to think about a recipe for better cognitive ageing: rather than finding that one single thing has a huge risk, we see lots and lots of factors that each probably contributes a little bit to your risk for cognitive ageing,” Cox said.

“Even though they were all the same age, some brains looked perfectly healthy ,” he said. “Whereas others showed lots of shrinkage and damage to the white matter connections, along with other features that are related to cognitive ageing and dementia.” “Not all of the aspects of brain ageing happen together in the same people,” Cox said. “We are now looking into whether different constellations of brain ageing features are driven by particular subsets of risk factors.

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