The results may shed light on what's going on in humans.
“At the time we were working on our study there were one or two reports out there describing people who had vaped and had sterile pneumonias,” said senior study senior author Dr. Farrah Kheradmand, a professor of medicine, pathology and immunology at the Baylor College of Medicine. “The reports showed staining of cells within the lung that looked identical to what our mice had.”What Kheradmand’s mice had was immune cells in the lungs that had become clogged up with fat.
The exposure to smoke, vapor or air lasted four months, which would be comparable to years of smoking in humans, Kheradmand said. Immune cells isolated from the lungs of mice exposed to chronic vape , but not air or smoke, show large abnormal translucent bodies inside the cells . Lower images show that the abnormal translucent bodies are full of fat. The study was funded by the NIEHS.The researchers initially thought the fat particles, or lipids, filling up the immune cells had come directly from the vegetable glycerin, which is a type of fat. But as it turned out, the fat had come from the animals’ own lungs.
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