Understanding how the brain processes perception into action

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Understanding how the brain processes perception into action
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You hear a phone ring or a dog bark. Is it yours or someone else's? You hear footsteps in the night -; is it your child, or an intruder? Friend or foe? The decision you make will determine what action you take next.

May 10 2024Champalimaud Centre for the Unknown You hear a phone ring or a dog bark. Is it yours or someone else's? You hear footsteps in the night -; is it your child, or an intruder? Friend or foe? The decision you make will determine what action you take next. Research ers at the Champalimaud Foundation have shed light on what might be going on in our brains during moments like these, and take us a step closer to unraveling the mystery of how the brain translates perceptions into actions.

A different approach The researchers tackled these queries by devising a task for mice. Postdoc Raphael Steinfeld, the study's lead author, picks up the story: "To unravel what signals related to future actions might be doing in sensory areas, we thought carefully about the task mice would have to perform. Previous studies often relied on "Go-NoGo" tasks, where animals report their choice by either making an action, or not moving, depending on the identity of the stimulus.

Deep connections After six months of rigorous training, the researchers could finally begin recording neural activity in mice as they performed the task. They focused on the auditory cortex, the part of the cortex responsible for processing what we hear, which they had already shown was required for the task.

Origin and role of choice signals So, what might the origin of these choice signals in the auditory cortex be? "Interestingly", notes Renart, "the early sensory signals in the auditory cortex don't seem to predict the mice's eventual choice, and the choice signals emerge significantly later.

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