Though scientists have made progress in understanding neuronal regeneration, according to the researchers, it remains unknown why some neurons regenerate and others do not.
In a study published Monday, researchers from the UC San Diego School of Medicine found a new marker to determine whether neurons — the main cells that make up our brain and spinal cord — will regenerate after an injury.
The study, published Monday in the journal Neuron, details how the authors used single-cell RNA sequencing, a method that determines which genes are activated in individual cells. The UCSD School of Medicine researchers tested their new biomarker discovery in mice, finding it was"consistently reliable in neurons across the nervous system and at different developmental stages.
The researchers analyzed gene expression in neurons from mice with spinal cord injuries. They"encouraged these neurons to regenerate using established molecular techniques, but ultimately, this only worked for a portion of the cells," a UCSD statement reads. To validate their findings, the researchers tested this molecular fingerprint — which they named the Regeneration Classifier — on 26 published single-cell RNA sequencing datasets. These datasets included neurons from various parts of the nervous system and at different developmental stages.
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