Researchers have developed a noninvasive way of using bioluminescent optogenetics to activate parts of the brain.
University of Rochester researchers have demonstrated a noninvasive method using BL-OG, or bioluminescent optogenetics, that harnesses light to activate neurons in the brain. The ability to regulate brain activation could transform invasive procedures such as deep brain stimulation that are used to treat Parkinson's disease and other neurological conditions.
Combining these tools creates the material needed for BL-OG. But in order to work, BL-OG still needs something to"turn on" the light. The organic substance luciferin, when combined with bioluminescence, creates light that activates the optogenetics and modulates cellular response in the brain without an incision. Previous work by Gomez-Ramirez has shown that the chemical luciferin is harmless to the body.
Researchers were also able to track the neuromodulation effects of BL-OG through the bioluminescent activity, another potential feature of this method that could provide insight into how the brain works.Chemists have developed a tool for noninvasive brain imaging that can help illuminate hard-to-access structures and processes. Their small-molecule dye is the first of its kind that can cross the ...
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