Scientists discover that a mutation in the gene CDKN2A makes cancer cells more vulnerable to being eliminated.
ability to use energy and nutrients to grow, thrive, and infiltrate healthy cells is thought to be one of the keys to developing novel, efficient therapies.
The scientists subsequently utilized a drug that targets this pathway. They found that glioblastoma cells with the CDKN2A genetic change were far more likely to experience cell death than those without the alteration. "Importantly, we found that CDKN2A deletion rewires lipid metabolism not just in our models but also in tumors from glioblastoma patients. This indicates that this metabolic vulnerability could one day be a target of therapy in glioblastoma patients."
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