An oral medication approved to treat multiple sclerosis (MS) could also put the brakes on inflammation thought to play a role in the development of Alzheimer's disease, new research suggests.
For some reason, microglia can also switch into overdrive, prompting them to flood their surroundings with signaling chemicals called cytokines that puts the tissues into a state of high alert.
Since the same sphingolipid that gives T and B cells a hall pass also activates receptors on the microglia, Bieberich and his team wondered if a drug like ponesimod might flick microglia's switches, forcing them to silently focus their efforts on clean-up. So far the results look encouraging, with clear signs that ponesimod reduces pro-inflammatory cytokines and triggers anti-inflammatory signaling that encourages microglia to gobble up troublesome protein clumps and tangles in the brain.
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