Scientists have discovered DNA-damaging molecules made by gut bacteria that may help explain why people with inflammatory bowel disease (IBD) have higher rates of colorectal cancer than those without the condition.
, which causes inflammation in all or part of the digestive tract, most commonly in the small intestine.)
From these strains, the scientists identified individual molecules that the bacteria produced and tested which ones caused DNA damage. "These data thus implied the existence of previously unrecognized microbiota-derived genotoxins," the researchers wrote in their report., which was previously reported to be prevalent in both IBD and colon cancer patients' guts.
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