Antiretrovirals have essentially made HIV a chronic, manageable illness
In health care, we tend to spend a lot more time bemoaning failures than pondering successes. We too often lose sight of the fact that, while progress often comes gradually, the cumulative effect can be impactful.with human immunodeficiency virus over the past four decades, and 42.3 million of them having succumbed to AIDS, it remains one of the worst pandemics in history.
Most of the patients received stem cell transplants from donors who carried a rare genetic mutation known as CCR5-delta 32, which makes them naturally resistant to HIV. But two of the donors did not have that mutation, and that’s important too. The treatments we have, antiretrovirals, keep the virus from replicating, but don’t kill the hidden virus. That means patients need to keep taking ARVs for life – often daily – to avoid illness. The drugs are a functional cure, but a tough slough.
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