Nature research paper: The neurons that restore walking after paralysis
neurons, were prioritized in specific comparisons involving the long-term recovery of walking following EESneurons that receive a twofold increase in the density of projections from SC. This reorganization may contribute to the overall decrease in the number of transcriptionally active neurons during walking in response to EESUnderstanding the contributions of each neuronal subpopulation to complex behaviours such as walking is a fundamental challenge in neuroscience.
They are currently followed-up on a regular basis by the study team for up to six years. To date, a total of nine individuals completed the main part of the study. Their neurological status was evaluated according to the International Standards for Neurological Classification of Spinal Cord Injury , and is reported in Supplementary TableIn humans, EES was delivered using a paddle lead that was surgically implanted over the epidural surface of the lumbar spinal cord.
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