Hereditary factors that increase the likelihood of cancer mutations detailed in new study NatureComms
]. From STRING we only kept interactions which had a combined confidence score of at least 80%. The following steps were performed for each protein network separately.
Firstly, we extracted all interactions which involved interactions between genes from our pre-selected gene list of 891 genes. We calculated the total number of interactions our replicated genes had at an empirical FDR of 1% with each other. It was tested via randomization whether this number was higher than one would expect at random. For this purpose, we selected randomly the same number of genes and calculated the total number of interactions these genes had with each other.
Next, we counted how many genes, which only replicated at an FDR of 2%, had at least one interaction with a gene which replicated at an FDR of 1%. Here, we applied the same approach. We counted the total number of interactions each gene, which only replicated at an FDR of 2%, had in total and split the number of interactions into 10 equal-sized bins.
To compare variant frequencies between cancer datasets and gnomAD, all variants which were detected in the cancer datasets and in gnomAD v2.1.1 were retained. Rare pLoF variants in the cancer datasets which were previously not detected in gnomAD were removed in order to remove potential biases due to technical reasons.
Canada Latest News, Canada Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects - Nature MedicineAn analysis of blood samples from longitudinal cohorts reveals insights on the dynamics of clonal hematopoiesis of indeterminate potential and proposes a model that could be used for individualized clone monitoring over time.
Read more »
Debroah James' Podcast Co-Host Lauren Mahon Pays Emotional Tribute To 'A Fabulous Force Of Nature''The person we miss is the deviant, our Deb. The woman who had the most outrageous cackle... and the twinkle in her eye.'
Read more »
New Omicron variant becoming dominant Covid strain in LincolnshireNew Omicron variant becoming dominant Covid strain in Lincolnshire
Read more »
Northants health boss urges unwell to stay off to stop CovidFigures show cases are on the rise due to a new fast-spreading sub-variants of Omicron.
Read more »