The hunt for drugs for mild COVID: scientists seek to treat those at lower risk

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The hunt for drugs for mild COVID: scientists seek to treat those at lower risk
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People who are unlikely to develop severe COVID-19 have no widely approved medications to ease the illness.

A shift is afoot in the search for COVID-19 therapies: some researchers are turning their attention towards drugs that could be used to treat mild illness, even in people who are not at high risk of severe disease.

Political hurdles and recruitment issues have dissuaded some researchers from shifting their focus away from severe disease, but others are pushing ahead. “This could still be really important — to look at decreasing time spent ill,” says Susanna Naggie, an infectious-disease clinician at Duke University School of Medicine in Durham, North Carolina.

Low-income countries could also benefit. For example, in the Democratic Republic of Congo, only 3.3% of the population has received a vaccine dose. But drugs could help to compensate for low vaccation rates, says Frédéric Monnot, a drug-development researcher at the Drugs for Neglected Diseases Initiative in Geneva, Switzerland. Many drugs are easier to deploy in Africa than vaccines, which often require cold storage and must be administered by trained personnel.

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