Researchers find link between genetic mutations and cancer treatment resistance umich NatureComms
were detected in peripheral blood in a subset of RRMM patients, these genes should be included in CTC screening panels employing next-generation sequencing. Interestingly, despite our unbiased effort to search for the enrichment of mutations and copy-number alterations in RRMM compared to NDMM, a genetic basis for resistance against proteasome inhibitor drug class remains elusive.
Another clinically relevant aspect of our study concerns the monoclonal antibodies targeting CD38. Although potent as MM therapies, they were subject to resistance mutations and copy losses, according to our analyses. Two of our patients harbored distinct mutations that converged into the in-frame exon skipping affected codons 221 to 250, presumably only disrupting the epitope of daratumumab while retaining a major portion of the extracellular domain.
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