Dr. Stanley Plotkin invented the rubella vaccine at the Wistar Institute, which is credited with eradicating the disease in the U.S. in 1964. He is now consulting for pharmaceutical companies on vaccine development to halt the COVID-19 pandemic.
How has vaccine-creation technology changed since the '60s?
It happened for a reason, which would not be repeated today. One of the competing vaccines was actually developed at the licensing authority, a branch of the. For a pharmaceutical manufacturer, that was very appealing, because it meant that they would get a license for the vaccine because they'd be working with the licensing authority.
The FDA does not develop vaccines [anymore]. [Plus], there are so many more ways to develop vaccines that you have multiple candidates, which is great. For two reasons — one, because until you have large-scale use of a vaccine, you don't know everything about it; you don't know for sure whether your expectations about the vaccine are right. It may be that something you thought was not as good turns out to be better than the one that you thought was the best. It's only in use that you really can make that judgment.
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