In preclinical models, investigators uncovered a novel mechanism underlying the development of diabetic cataracts that undermines current hypothesis. Researchers at Brigham and Women's Hospital have discovered a novel mechanism in the development of diabetic cataracts, challenging the long-held '
New findings challenge the “sugar hypothesis” in diabetic cataracts, revealing that immune cells cause cellular changes in the eye lens before high blood sugar levels occur. This suggests diabetic complications may begin during the pre-diabetic state and calls for a reevaluation of current theories.
Researchers at Brigham and Women’s Hospital have discovered a novel mechanism in the development of diabetic cataracts, challenging the long-held “sugar hypothesis.” Their study revealed that immune cells migrate from the eye’s ciliary bodies towards the lens, resulting in cellular changes that compromise lens function. These changes occur even before high blood sugar levels are present, suggesting that diabetic complications may begin during the pre-diabetic state.
Immune cell trafficking in diabetic cataract formation. Novel in situ visualization technique for studies of immune cell trafficking in the eye. Immune cell passing through ciliary body’s epithelial cells. Microstructural lesions in the early phases of diabetic cataract formation. Credit: Images provided by Hafezi-Moghadam et al.spontaneously develops type 2 diabetes when kept in captivity and closely mimics the condition in humans.
While still too early to tell what exactly causes the immune cells and epithelial cells to behave the way they do, the researchers conclude that their study urges further investigation of prevailing theories. It may also bring the medical community a step closer to understanding the cellular mechanisms underlying the origins of diabetic complications during the pre-diabetic stage of the disease.
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