Examining the placenta may help identify the cause of most unexplained pregnancy losses, US researchers found, with signs of pathology in its tissues uncovered in more than 90 percent of their studied cases.
Because it is so important, changes in this temporary organ can lead to miscarriage or stillbirth. The researchers investigated whether adding two categories of placental pathology to the existing recorded ones would help explain the losses.says"Our goal was to expand the current classification systems to decrease the number of cases that remained unspecified."
By examining placental pathology slides from each case, the team found that nearly 92 percent of cases could be diagnosed with a specific placental pathology. This included over 85 percent of miscarriages and almost 99 percent of stillbirths. Due to the difficulty of safely evaluating this organ during pregnancy, doctors and researchers have historically overlooked the placenta. In 2009, Kliman was part of a duo that developedWhile the test takes just 30 seconds, most physicians still don't do it.
The large sample size and range of timing of losses give the research merit, though the study also has limitations. It was retrospective so it can't establish a causal relationship between placental pathology and pregnancy loss. And it was conducted at a single institution, so the results may not be generalizable to other populations.
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