According to this new study, viral-vectored delivery of anti-Müllerian hormone is a promising lead for safe and durable long-term contraception in female domestic cats.
Unlike traditional contraceptive methods, this method works by inhibiting the activation of primordial follicles, the initial structures that give rise to mature eggs. By preventing the activation of these early follicles, the contraceptive method effectively interrupts the reproductive process and prevents pregnancy.
AAV9 is a virus commonly used as a delivery system, or vector, in gene therapy. It was chosen because it prefers muscle tissues and is not usually blocked by antibodies in cats, making it an effective gene delivery vehicle. This meant the genes functioned as intended and were ready to be tested in cats. The AAV9-fcMISv2 was administered to nine female cats with no significant adverse effects or immune responses.
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