Study finds new biomarkers that could assist in identifying deep-space flight risks Livermore_Lab
"Something about spaceflight changed the amount of RNA in the astronauts' blood," Coleman said."They were in key pathways that regulate transcription, cell-to-cell signaling and intercellular signaling.
"Because the lncRNA can modulate a large number of genes, understanding those genes and the pathways they're associated with—such as general health or cardiovascular disease—would allow us to identify who needs to get specific medicine, change their diet or get more exercise to ward off any negative effects of spaceflight," Coleman said.
Nearly all past studies have focused on the effects of space on astronauts in low-Earth orbit, such as shuttle astronauts working aboard the International Space Station. The LLNL capabilities that aided the team's study included 30 years of expertise in genomic science, DNA repair and researching the effects of ionizing radiation through sequencing for the Human Genome Project.
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