A hybrid biomaterial that has been successfully synthesized could be utilized to treat spinal injuries. A unique material developed at the University of Limerick in Ireland has demonstrated considerable potential in the treatment of spinal cord injuries. Exciting new research conducted at the Be
Spinal cord injuries are a serious and debilitating condition that occurs when there is damage to the spinal cord, which can result from a traumatic injury, such as a car accident, fall, or sports injury, or from a non-traumatic cause, such as infection, inflammation, or a tumor. The severity of a spinal cord injury depends on the location and extent of the damage.
The UL team led by Professor Maurice N Collins, Associate Professor, School of Engineering at UL, and lead author Aleksandra Serafin, a Ph.D. candidate at UL, used a new kind of scaffolding material and a unique new electrically conducting polymer composite to promote new tissue growth and generation that could advance the treatment of spinal cord injury.
The research team describes a growing interest in the use of electroconductive tissue-engineered scaffolds that have emerged due to the improved cell growth and proliferation when cells are exposed to a conductive scaffold. Novel PEDOT nanoparticles were developed in the study to overcome this limitation. Synthesis of conductive PEDOT NPs allows for the tailored modification of the surface of the NPs to achieve desired cell response and increase the variability of which hydrogel components can be incorporated, without the required presence of PSS for water solubility.
Testing showed greater axonal cell migration towards the site of spinal cord injury, into which the PEDOT NP scaffold was implanted, as well as lower levels of scarring and inflammation than in the injury model which had no scaffold, according to the study.
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