Spatial and genetic information captured for cancer subclones.
As a cancer grows and changes, its cellular lineages evolve through mechanisms that echo the evolutionary steps that give rise to new species. Although cancers are thought to emerge from a single cell, multiple rounds of division, mutation and natural selection promote cellular diversification, resulting in a tumour lineage that forms a ‘tree’ of genetically related, yet distinct, populations of cells called subclones.
. How different cancer subclones emerge, interact with each other, and shape and are shaped by the TME, remains to be fully understood.
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