A new study suggests that, yes, there are COVID-19 superdodgers. But explaining why they've been able to avoid the virus is a bit complicated.
with CRISPR. But it did something else: It showed scientists that one mutation could make a person completely resistant to an infection. One mutation in their genes could make them a true superdodger.“So when SARS-CoV-2 came along, of course, many labs looked to see if the same might be true for this virus,” Landau says. And inspired by the story of CCR5, they went looking for mutations in the genes required for SARS-CoV-2 to enter and infect cells.
“Of course, there may be more subtle mutations in ACE2 which could play a role in resistance to SARS-CoV-2,” he adds. “But there doesn’t seem to be an obvious and dramatic mutation as is the case for HIV.”than ACE2, and these mutations probably don’t protect them from getting infected per se but do protect them from getting sick.So having one of these mutations would make you a sort of COVID mini-dodger, if you will.
When a virus first enters cells, HLA signals to the immune system that cells are invaded and need help. That signal triggers a cascade of events that ultimately leads your body to make potent weapons specifically designed to fight SARS-CoV-2. These weapons include antibodies and T cells that uniquely recognize pieces of this virus. Once these targeted weapons are available, your immune system has a much easier time clearing up the infection. But these weapons take time to manufacture.
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