Scientists use intratumoral immunotherapy to tame pancreatic cancer. Houston Methodist nanomedicine researchers have discovered a method to control pancreatic cancer, a highly aggressive and challenging form of the disease, by administering immunotherapy directly to the tumor using a device smaller
Houston Methodist Research Institute nanomedicine researchers used an implantable nanofluidic device smaller than a grain of rice to deliver immunotherapy directly into a pancreatic tumor. Credit: Houston Methodistnanomedicine researchers have discovered a method to control pancreatic cancer, a highly aggressive and challenging form of the disease, by administering immunotherapy directly to the tumor using a device smaller than a grain of rice.
Pancreatic ductal adenocarcinoma is frequently diagnosed at advanced stages. In fact, about 85% of patients already have metastatic disease at diagnosis. Immunotherapy holds promise in treating cancers that previously did not have good treatment options. However, because immunotherapy is delivered throughout the entire body, it causes many side effects that are sometimes long-lasting, if not life-long. By focusing the delivery directly into the tumor, the body is protected from being exposed to toxic drugs and has fewer side effects, essentially allowing patients undergoing treatment to have a better quality of life.
The NDES device consists of a stainless-steel drug reservoir containing nanochannels, thus creating a membrane that allows for sustained diffusion when the drug is released.
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