Immunotherapy has proven to be a successful treatment approach for various cancer types, but its efficacy in pancreatic cancer is limited and exhibits disparities between men and women. Scientists at the Karolinska Institute have potentially uncovered the reason behind this gender discrepancy. Their
Pancreatic cancer is a formidable and often aggressive form of cancer that arises in the pancreas, a vital organ responsible for producing hormones and digestive enzymes. This disease is particularly challenging to diagnose and treat, as it often goes unnoticed until it reaches advanced stages.
, identifies an immune cell present in women with pancreatic cancer that hinders the body’s immune response. These findings could lead to the development of more tailored, gender-specific treatments. In recent years, immunotherapy, which stimulates the immune system to attack cancer cells, has contributed significantly to the treatment of different kinds of cancer, such as melanoma and lung, kidney, and liver cancer. However, it is much less effective against pancreatic cancer, which remains one of the deadliest kinds of cancer that leaves patients, on average, with four to six months left to live after diagnosis.
“This sub-group of immune cells correlates with poor survival exclusively in female cancer patients,” says the study’s corresponding author and principal investigator Dhifaf Sarhan, assistant professor at the Department of Laboratory Medicine, Karolinska Institute. “Our results show that the immune cells express a specific protein called FPR2 and can serve both as a sex-specific prognostic factor and a therapeutic target.
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