A team of researchers has taken an important step toward a future where we can regenerate human teeth with the use of stem cells.
, the researchers created organoids, which are three-dimensional scaffolds of stem cells that mimic the functions of organs, to secrete proteins that eventually turn into dental enamel, the hard material that protects teeth from decay or damage.
The researchers recovered special genetic instructions for assembling these proteins through a technique called "single-cell combinatorial indexing RNA sequencing." After a substantial amount of trial and error, the researchers were able to turn human stem cells into ameloblasts by activating genetic pathways using that blueprint.
But plenty of challenges remain until we can induce the regrowth of enamel in human patients. Zhang and his colleagues are now working on new ways to create enamel that is as hard as the stuff found in natural teeth.
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