Scientists have identified the OBOX gene family as a plausible candidate.
“For the embryo to develop, the oocyte/egg has to lose its identity and does so by making new stuff. We now know the first steps in how this transition occurs,” said Richard Schultz, a research professor at the university, in anThe team lab has identified the OBOX gene family as a plausible candidate. They discovered that this family consists of eight genes , with genes OBOX1, 2, 3, 4, 5, and 7 identified as possible candidates for early development.
Interestingly, this zygote genome activation is said to be conserved throughout species but with different genes. In mice, it was found that activation occurs at the two-cell stage. While in human embryos, genome activation happens after the embryo has formed about eight cells.activation. “The work also has implications for understanding how embryonic stem cells are reprogrammed so that they can develop into any tissue of the body,” the statement concluded.Zygotic genome activation activates the quiescent genome to enable the maternal-to-zygotic transition1,2. However, the identity of transcription factors that underlie mammalian ZGA in vivo remains elusive. Here, we showed that OBOX, a PRD-like homeobox domain TF family 3-5, are key regulators of mouse ZGA.
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