Scientists have repurposed human stomach cells into tissues that release insulin in response to rising blood sugar levels in a breakthrough that promises an effective way to manage conditions such as type 1 diabetes.
The experiment, led by researchers from Weill Cornell Medicine in the US, revealed transplants of gastric insulin-secreting cells reversed diabetes in mice.
"The stomach makes its own hormone-secreting cells, and stomach cells and pancreatic cells are adjacent in the embryonic stage of development, so in that sense it isn't completely surprising that gastric stem cells can be so readily transformed into beta-like insulin-secreting cells,"Scientists have been trying to get
The reprogramming process is highly efficient, and when the cells were grown in small clusters known asthey showed sensitivity to glucose. They were then able to show long-lasting effects on diabetes in mice. The insulin hormone is crucial in regulating blood glucose. Without sufficient levels we run the risk of a variety of health complications. Millions of people worldwide live with diabetes, mostly using insulin injections to help keep glucose levels under control.
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