Scientists from Karolinska Institutet, in collaboration with Karolinska University Hospital, have uncovered the root cause of Langerhans cell histiocytosis. These groundbreaking findings, published in the journal Science Immunology, could pave the way for new, targeted treatments for LCH patients.
have now been able to show that both theories are close to the truth. The researchers combined so-called single-cell sequencing, the microscopy of samples, and the tracking of cells from patients recruited from, among others, Karolinska University Hospital.
“Today we know that DC3 has a separate pathway of development, separate from other dendritic cells and monocytes, and knowledge of this was crucial in our study,” says Egle Kvedaraite. “Among the treatment options for LCH, targeted therapy can be successfully applied, but the disease comes back when the targeted treatment is discontinued. This poses a serious challenge for patients, as a lifelong treatment for children is not a good option given the side effects,” says Egle Kvedaraite.
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