The study delves into a 20\u002Dyear\u002Dold theory
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Often, scientists can instead learn the role an individual gene plays by observing what happens when that gene is knocked out of cells in a lab dish. But knocking out 425 genes one by one is time-consuming. This was all the more remarkable because in living brains, the region of the subpallium that makes interneurons is not right next to the cerebral cortex, but is inches away, Pasca said.
Using the fused clumps of cells, the researchers “performed by far the largest screen for autism and [neurodevelopmental disorder] genes,” Guo-li Ming, a professor in the departments of neuroscience and psychiatry at the University of Pennsylvania, wrote in an email commenting on the study.
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