Research published in BMCInfectDis found that convalescent plasma treatment reduces hospital length of stay but not SARS-CoV-2 viral load, ICU requirement, mechanical ventilation, or mortality.
Comparative genomics and nucleotide diversity analyses among SARS-CoV-2 genomes obtained in this study.Whole-genome substitutions profiles for the eleven genomes from five patients with more than one sample. Mismatches were identified by comparison with the Wuhan reference sequence . The substitutions shared among each group of samples are represented in grey and the substitutions found on any of the sample's days are represented in Red or light green .
We identified substitutions in the five patients in whom samples were obtained for genotyping before and after treatment . For patient 1 , we identified sixteen substitutions; fourteen were shared among all the days sampled, and two were found on only one of the days. On day zero, one substitution was identified, located in the ORF1ab , and on day 14, an additional substitution in the Spike . Fourteen substitutions were identified in patient 2 .
Regarding patient 3 , sixteen substitutions were identified. Nine were shared among all the days sampled, and seven substitutions were found in only one of the days sampled but not on the others. On day zero, four substitutions were found and one in the S ) and three substitutions on day 7 . For the case of patient 4 ; seven substitutions were found in only one of the sampled days, two of them identified on day zero and five on day 14 .
There were no differences in the distribution of variants by treatment . In addition, none of the variants were associated with ICU admission , mechanical ventilation , or death .In this study, conducted on severe COVID-19 patients, CP was associated with a shorter hospital stay and early clinical recovery. As expected, CP was associated with higher levels of IgG antibodies post-transfusion, but this phenomenon was not associated with viral load reduction.
It has been suggested that administration of a high titer of anti-SARS-CoV-2 IgG antibodies could be associated with better clinical outcomes in COVID-19 [
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