By monitoring the body’s molecular response to a viral attack, the new method developed by Flatiron Institute researchers and their colleagues can diagnose even asymptomatic patients with 98.4 percent accuracy. By inspecting the body’s immune response at a molecular level, a research team has dev
A new method can quickly diagnose COVID-19 more accurately than existing approaches. The technique is based on how the body expresses genes in response to infections. When a gene is expressed, different segments of the gene create different mRNA isoforms. The mix of those isoforms changes the types of proteins produced, including proteins involved in fighting viruses.
, the virus that causes COVID-19. When the assault starts, specific genes turn on. Segments of those genes produce mRNA molecules that guide the building of proteins. The particular blend of those mRNA molecules changes the types of proteins produced, including proteins involved in virus-fighting functions. The new method can confidently identify when the body is mounting an immune response to the COVID-19 virus by measuring the relative abundance of the various mRNA molecules.
The researchers tuned their method using blood samples from a 2020 study of U.S. Marine recruits taken before and after the participants caught COVID-19. The researchers’ computational framework identified more than 1,000 disease-associated mRNA-variant ratio changes.
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