More detailed tracking of virus genetic variations can provide early warning to public health efforts. Researchers at Case Western Reserve University (CWRU) genetically sequenced the viral infections in 360 COVID patients. They found wide genetic variation in SARS-CoV-2 viruses, showing that all
According to a new research study, all individual COVID-19 infections include multiple variants of the SARS-CoV-2 virus.
Researchers at Case Western Reserve University genetically sequenced the viral infections in 360 COVID patients. They found wide genetic variation inReporting about the virus usually highlights a single dominant strain, the researchers noted. This leads to under-reporting virus genetic variation and can have serious consequences in public health planning and response.
Whole genome sequencing of 140 COVID samples from infected individuals between April 2020 and August 2021 show infection signatures consistent with the major strain at the time represented in different color partitions. Each horizontal line illustrates a sequenced sample, and lineage-specific positions are shown vertically. Gray shaded boxes represent mixed allele frequencies observed in our samples.
“Concentration on a majority consensus of virus variants within the global research community diverts attention from genetic variation that may contribute significantly to the continuing evolution of the COVID-19 pandemic,” said Peter Zimmerman. He is a professor in the Department of Pathology at the School of Medicine.
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