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Research Associate Position in ALS Research

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Research Associate Position in ALS Research
ALSResearchCell Biology

A Research Associate position is available at a UK-based research institute focused on understanding the mechanisms underlying Amyotrophic Lateral Sclerosis (ALS) using cutting-edge human CNS organoid models and patient samples.

This exciting wet lab-based research project lies at the intersection of basic biology and translational science , within the UK EXPERTS- ALS platform programme. The successful candidate will explore the interactions between genomic changes and molecular pathways relevant to early pathologies and the progression of ALS using cutting-edge human CNS organoid models/tissue engineering and patient samples.

The research may also involve drug testing in translational in vitro platforms and mechanistic target-engagement studies that inform the clinical trial programme. This post is a unique opportunity for an enthusiastic cell or molecular biologist with an aptitude for semi-independent work, well supported by a dynamic team. The Research Associate will also be supported by experts in computational biology in the lab and be expected to interact within the EXPERTS-ALS network and with collaborating groups at Harvard University, the Wellcome Trust Sanger Institute and the MRC-WT Cambridge Stem Cell Institute. Fellowship applications will be encouraged towards the end of the post. The candidate must have a PhD or MD in biological or medical sciences and practical experience with stem cell or cell-line cultures, general cell and molecular biology methods, vector preparation, and cloning. Further experience in one of the following specific areas is desirable: human stem cell- or organoid-based cultures, genetics and CRISPR-editing, single-cell transcriptomics, proteomics, or molecular pathology expertise. The candidate will join a multidisciplinary group of basic and clinician scientists to pursue fundamental and clinically relevant questions in neurobiology

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