Results of a study of Regeneron Pharmaceuticals Inc and Sanofi SA's rheumatoid arthritis drug Kevzara indicate it may only help the sickest coronavirus patients, the companies said on Monday, dampening hopes the medicine could benefit a wider group of those infected.
- Results of a study of Regeneron Pharmaceuticals Inc and Sanofi SA’s rheumatoid arthritis drug Kevzara indicate it may only help the sickest coronavirus patients, the companies said on Monday, dampening hopes the medicine could benefit a wider group of those infected.
Patients who required mechanical ventilation or high-flow oxygen therapy or treatment in an intensive care unit were considered critically ill. Those who required oxygen without mechanical or high-flow oxygenation were considered severely ill. “Repurposing a drug and finding it to be very effective for a new indication is an exception, as opposed to the rule,” Yancopoulos said. “It’s very, very rare where those have really turned into important drugs for whole new indication.Regeneron has identified hundreds of virus-neutralizing antibodies and is working to select the best two candidates for a “cocktail” therapy that might treat and even prevent COVID-19, with the expectation of starting human trials in June.
Researchers were looking for reductions in risk of death and need for a ventilator, as well as clinical improvements such as ability to come off oxygen therapy or be discharged from the hospital. Those who received the higher tested dose of Kevzara appeared to fare better among the critically ill group.
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