A Nature Research paper reports that a small but significantly increased likelihood of being childless is associated with damaging mutations in selectively constrained genes
We thank L. Parts, J. Kaplanis, M. Przeworski and G. Davey-Smith for useful discussions and advice on data analysis; M. Oud and J. Veltman for helpful discussions regarding infertility; G. Kalantzis and P. F. Palamara for assistance with correcting for recent ancestry; and the INTERVAL study for sharing genotyping and exome data that enabled us to refine our CNV filtering methodology.
is supported by a fellowship from the Bank of Sweden Tercentenary Foundation . This work has been conducted using the UK Biobank Resource under application numbers 14421 and 44165 .Present address: Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UKEugene J. Gardner, Matthew D. C. Neville, Kaitlin E. Samocha, Mari E. K. Niemi, Hilary C. Martin & Matthew E.
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