Prof. Wang Sibao from Center for Excellence in Molecular Plant Sciences of the Chinese Academy of Sciences and his colleagues have revealed that quorum sensing-activated phenylalanine metabolism drives outer membrane vesicles (OMVs) biogenesis to enhance commensal colonization resistance to Plasmodium in the mosquito gut. The study was published online in Cell Host & Microbe.
Mosquitoes depend on blood ingestion for propagation, while blood digestion induces hyper-oxidative stress on gut microbiota. The researchers discovered that commensal Serratia bacteria form biofilm-like aggregates in the midgut of blood-fed mosquitoes, suggesting that high-order aggregation facilitates commensal colonization of the gut. They found that these bacterial aggregates are highly ordered and driven by OMVs.
Using comparative transcriptional analysis, they found that both C6-HSL treatment and SueR deletion lead to the same metabolic signaling remodeling pattern involving the activation of a critical phenylalanine cassette. These findings showed that QS triggers the activation of phenylalanine metabolism to drive the biogenesis of Serratia OMVs in the gut. These OMVs contribute to the formation of bacterial aggregates and facilitate gut colonization.
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