When added to prostate biopsy, gallium-68 PSMA-PET/CT improves detection of clinically significant prostate tumors and helps guide treatment planning, new research shows. EAU2023
MILAN — When added to prostate biopsy, gallium-68 prostate-specific membrane antigen -PET/CT improves detection of clinically significant prostate tumors and helps guide treatment planning, new research shows.
"PSMA-PET/CT seems to influence our actions during prostate cancer diagnosis," said Phillip Krausewitz, MD, from University Hospital Bonn, in Bonn, Germany, who highlighted the findings during an oral abstract presentation at the EAU meeting. "In 2023, it's not a practical screening tool, given its very, very high costs," Mark Pomerantz, MD, of the Dana-Farber Cancer Institute in Boston, toldPSMA-PET/CT has already been shown to improve detection of prostate cancer metastasis and local T-staging in combination with MRI.
On the basis of these findings, risk stratification and patient management plans were developed. Patient records were randomly assigned to different evaluation teams: one team received all results, including findings from PSMA-PET/CT-guided biopsy, and one team received the MRI findings. The subsequent management plans, developed by independent urologists, were then compared.
The addition of PSMA-PET/CT also resulted in a 3% increase in diagnoses of clinically significant cancers and a 1% decrease in detection of nonsignificant cancers. PSMA-PET/CT is"very good at detecting very small tumors, including tumors that are making PSAs [prostate-specific antigen levels] of less than 1 [ng/mL], and in theory, it could be helpful one day in screening for the disease," but it"hasn't been extensively studied as a screening tool," said PomerantzIt's still unknown, however, what the false positive rate is and whether the technology could lead to overtreatment as a result of"chasing after every little...
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