.PPFA and ReproRights are suing the state of Kansas to block a new law that requires informing abortion patients of the potential to stop a medication abortion using a high dose of the hormone progesterone, also known as “abortion reversal.”
In the two-step process, mifepristone blocks a woman’s progesterone receptors. Because progesterone is necessary for fetal development, mifepristone is designed to stop the child’s growth in the womb. Within 48 hours after taking mifepristone, the abortion patient is instructed to take misoprostol to induce uterine contractions to expel the pregnancy.the brand name of mifepristone, Mifeprex, in 2000 and approved the generic version of the drug in 2019.
Planned Parenthood describes both the two-agent and single-agent medication abortion process as “similar to an early miscarriage,” with cramping and bleeding lasting between four and five hours or more.Taking a high dose of progesterone within 24 hours of taking mifepristone canthe effects of the first agent by essentially overloading the patient’s progesterone receptors. This minimizes the effects of the mifepristone and raises the patient’s progesterone levels.
Because of the relationship between progesterone and mifepristone, reversing a medication abortion with progesterone treatment is only possible after taking the first medication in the two-step process. Progesterone abortion reversal would be ineffective after taking misoprostol in the two-agent process or a misoprostol-only abortion because of the chemical causal mechanism of the drug.
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